TP53 and cancer: Compared with other cancers, the ABP-induced mutations are more evenly distributed along the p53 gene and the mutation hotspots occur at both CpG, such as codons 175, 248, and 273, and non-CpG sites, such as codons 280 and 285, the latter two being unique mutational hotspots for bladder and other urinary tract cancers [21].