It is well established that the BMM plays a prominent role in the biology of MM cells, since it elicits the production of cytokine, the enhancement of cell proliferation, and the resistance to chemotherapy by the activation of nuclear factor κB (NF-κB), PKC, PI3K/AKT, and JAK/STAT3 pathways through the largely characterized MM growth factor IL-6.7 The gene discussed is AKT1; the disease is Miyoshi myopathy.