A recent study reported that IL-6-induced oncogenic effects are mediated by the direct repression of miR-34a by STAT3 and that the p53-dependent expression of miR-34a suppresses tumor progression by inhibiting the IL-6R/STAT3/miR-34a feedback loop, being IL-6R a direct target of miR-34a.26 Here, STAT3 is linked to neoplasm.