It is well established that the BMM plays a prominent role in the biology of MM cells, since it elicits the production of cytokine, the enhancement of cell proliferation, and the resistance to chemotherapy by the activation of nuclear factor κB (NF-κB), PKC, PI3K/AKT, and JAK/STAT3 pathways through the largely characterized MM growth factor IL-6.7 This evidence concerns the gene STAT3 and Miyoshi myopathy.