Moreover, miR-125b-1 is implicated in a number of chromosomal translocations correlated with the occurrence of acute myeloid leukemia (AML) and B cell acute lymphoid leukemia (B-ALL) or myelodysplasia.59, 60 Despite that miR-125b dysregulation has been linked to tumor-promoting activity in different subtypes of leukemia61, 62, 63 and to drug resistance in some cases of MM,64 we have demonstrated that miR-125b acts as an oncosuppressor in MM by selective IRF4 inhibition.24 This evidence concerns the gene IRF4 and acute myeloid leukemia.