It appears that the enzymes ChEH, HSD11B1 and HSD11B2 and CYP27A1 sit at a fulcrum balancing the formation from 5α,6-EC of the tumour suppressor DDA and from 5,6-EC, through 3β,5α,6β-triol, the oncometabolite 3β,5α-diHC-6O or the bile acid 3β,5α,6β-triHBA. The gene discussed is HSD11B2; the disease is neoplasm.