POU2F1 and glioblastoma: For example, Ansari et al. [19] recently found that (i) the miR-451 transcription in GBM cells is induced by unrestricted activity of its transcription factor OCT1 (official gene symbol POU2F1) in the presence of abundant glucose, resulting in AMPK inhibition through direct targeting of CAB39 in the LKB1 complex; and (ii) the miR-451 level is inhibited through the phosphorylation and inactivation of OCT1 at S335 by AMPK in response to glucose depletion-induced metabolic stress, leading to a reciprocal negative feedback loop between miR-451 and AMPK.