HGF and metastatic malignant neoplasm: For instance, HGF and TGFβ are major regulators of EMT, and these also provide strong stimuli of GBM invasion [71, 72] and, upregulation of MET and CD44 activities, as well as an activated NFκB signaling pathway, was reported in both mesenchymal GBM and metastatic cancer [73–76].