Multiple linear regression revealed that CTRP3 independently associated with HOMA-IR (B [standard error] = -64.33 [23.02] and p = 0.007) and adiponectin (B [standard error] = 9.21 [2.63] and p = 0.001) in T2DM group as well as eGFR (B [standard error] = 0.953 [0.441] and p = 0.036) and HOMA-IR (B [standard error] = -62.773 [25.17] and p = 0.016) in T2DM-NP patients. Here, C1QTNF3 is linked to type 2 diabetes mellitus.