Inflammasomes are cytosolic multimeric protein complexes formed in inflammatory cells in response to infection and injury.3 The most studied inflammasome is composed of the cytosolic PRR (pattern recognition receptor) NLRP3 (NACHT [NAIP (neuronal apoptosis inhibitor protein), C2TA (class 2 transcription activator, of the MHC), HET-E (heterokaryon_incompatibility) and TP1 (telomerase-associated protein 1)], LRR [leucine-rich repeat] and PYD [PYRIN] domains-containing protein 3). The gene discussed is TEP1; the disease is infection.