HLA-E and cancer: Therefore, we emphasize that reliable immunodiagnosis of HLA-E on histopathological studies on tissues, mainly derived from cancer patients, require proof of monospecificity of the mAb for HLA-E, by the dosimetric inhibition of the HLA-E mAbs with one or more of the HLA-E monospecific epitopes listed in Tables 1 and 2.