Although most of them were recognized as shared sequences and polyreactive, 31 mAbs were monospecific.(54) We hypothesize that only the monospecific anti-HLA-E mAbs that are monospecific for HLA-E are not only useful for specific recognition of HLA-E on tumor cells and tissues but also can serve to prevent tumor escape from NIK cell killing by blocking by the interaction of the inhibitory NK cell CD94-NKG2A with tumor expressed HLA-E. The gene discussed is HLA-E; the disease is neoplasm.