Tumor cells may escape NKG2D–MICA-mediated immune attack by disulfide–isomerase-enabled proteolytic degrading and shedding of MICA.(18) Ferrari de Andrade et al.(19) have designed antibodies targeting the MICA α3 domain, the site of proteolytic cleavage for shedding, and found that these antibodies prevented loss of cell surface MICA and MICB in human cancer cells. The gene discussed is KLRK1; the disease is cancer.