The signature includes the genes PGBD1, OXR1, GZF1, ITGAX, ORC3, BMPR1B, KLK3, KLK2, NKX3-1, SLC22A3, POU5F1B, LMTK2, NAALADL2, LDAH, PDLIM5, SLC22A3, JAZF1, LMTK2, CASC8, DAP2IP, TIMM23B, MSMB, MYEOV, FLT1, SL35B4, and HNF1B containing genetic variants reported to be directly associated with aggressive PCa (Table 2) (references provided in supplementary Table SA). The gene discussed is KLK2; the disease is posterior cortical atrophy.