MDM4 and cancer: Among the most significant pathways included the PCa signaling pathway (P<5.81x10−6) with associated genes ATM, CTNNB1, FGFR2, KLK3, NKX3-1, and PIK3CA; the MSP-RON signaling pathway (P<1.54x10−5) with associated genes ATM, FGFR2, KLK2, KLK3, and PIK3CA and the P53 signaling pathway (P<1.24 x10−4) and the associated genes ATM, CTNNB1, FGFR2, MDM4, and PIK3CA; and the molecular mechanisms of cancer signaling pathway (P<3.19x10−4) with associated genes ATM, BMPR1A, BMPR1B, CTNNB1, FGFR2, FZD4, PIK3CA, and PLCB4.