The signature includes the genes PGBD1, OXR1, GZF1, ITGAX, ORC3, BMPR1B, KLK3, KLK2, NKX3-1, SLC22A3, POU5F1B, LMTK2, NAALADL2, LDAH, PDLIM5, SLC22A3, JAZF1, LMTK2, CASC8, DAP2IP, TIMM23B, MSMB, MYEOV, FLT1, SL35B4, and HNF1B containing genetic variants reported to be directly associated with aggressive PCa (Table 2) (references provided in supplementary Table SA). This evidence concerns the gene LDAH and posterior cortical atrophy.