Interestingly, the genes RNASEL, FTO, BMPR1A, ITGA6, TCF7L2, FREM1, LMTK2, and STAT3 containing germline mutations with weak to moderate associations were found to contain germline and somatic mutations and were differentially expressed between PCa and controls (Table 2). Here, TCF7L2 is linked to posterior cortical atrophy.