The second networks with a Z-score = 31 revealed the genes ATF7IP, CTNNB1, EIF2S3, FLG, FOXA1, FZD4, IKZF2, KCNN3, MACF1, PPFIBP2, PRDM15, PTPRD, SLC19A2, STAT3, TCF7L2, and TNS3 predicted to be involved in cancer, cellular development, and proliferation. This evidence concerns the gene TCF7L2 and cancer.