Cytokines, and particularly, tumor necrosis factor alpha (TNFα), impair mitochondrial oxidative phosphorylation and ATP production and increase reactive oxygen species (ROS), which in turn can increase mitochondrial injury and trigger mitochondrial content release to the cytosol, amplifying the inflammatory process [81].This interplay between the two processes may increase the risk of tumor development. This evidence concerns the gene TNF and neoplasm.