Fibroblast growth factor receptor 3 (FGFR3)-transforming, acidic coiled-coil containing protein 3 (TACC3) in glioblastoma [11] and chromosome 2 open reading frame 14 (C2orf44)-ALK fusions in colorectal cancer [12] are examples of tandem duplications (Figure 1D). Here, TACC3 is linked to glioblastoma.