EML4 and lung cancer: The fifth type of rearrangement is inversion, in which chromosomal segments flip with (pericentric) or without (paracentric) relationship with the centromere (Figure 1E); examples include kinesin family member 5B (KIF5B)-RET in lung adenocarcinoma [12] and echinoderm microtubule-associated protein-like 4 (EML4)-ALK in non–small cell lung cancer [13].