Binding of FGF ligands to FGF receptors engages downstream signaling pathways, including PI3K-AKT and RAS-ERK, while the constitutively activated FGFR3-TACC3 protein promotes ERK and STAT3 signaling cascades in glioblastoma, suggesting acquisition of neomorphic functions [11, 47]. The gene discussed is FGFR3; the disease is glioblastoma.