As seen in prostate cancer, the forced expression of normal proteins (i.e. 3′ gene, ETS family of transcription factors) through an androgen-responsive promoter (TMPRSS2, a transmembrane serine protease) or by fusion to ubiquitous promoters results in overexpression of a wild-type protein [17, 25–27]. The gene discussed is TMPRSS2; the disease is prostate cancer.