FGFR TK family (FGFR1, FGFR2, FGFR3, and FGFR4) members encode transmembrane proteins that contain immunoglobulin-like and kinase domains (Figure 2) that play diverse roles in controlling cell proliferation, cell differentiation, angiogenesis, and tumor development. This evidence concerns the gene FGFR2 and neoplasm.