Following 3 weeks of differentiation and maturation of DCs, and DC-mediated priming of T cells with irradiated lymphoma cell lines (Raji or SUDHL-10), the isolated T cells were investigated for cytotoxic activity against actively growing Raji or SUDHL-10 tumor cells, in the presence or absence of anti-PD-1, anti-TIM-3, or anti-LAG-3 experimental compounds. The gene discussed is PDCD1; the disease is neoplasm.