CD8A and neoplasm: Results from our experiments with initial tumor-primed CD8+ T cells against Raji cells showed that anti-LAG-3, but not anti-TIM-3, induced a potent dose-dependent increase in cell-mediated cytotoxicity with 15 nM IC50 compared to 61.25 nM IC50 using unprimed/resting T cells, as determined by AcellaTox-Glo assay (Figure 3A, 3B).