Considering that we observed PD-1, TIM-3 and LAG-3 expression in TILs, and TIM-3 expression in tumor cells of many cases of DLBCL, we next investigated the effects of blocking PD-1, TIM-3 and LAG-3 in the context of tumor-specific cytotoxic activity. The gene discussed is LAG3; the disease is diffuse large B-cell lymphoma.