At this point, considering that the patient was heavily pre-treated and showed resistance to standard cytotoxic chemotherapy and radiotherapy, in order to determine genomic predisposing variants for both tumors as well as predictive biomarkers useful to establish a rationale targeted approach, we performed simultaneously both: a) the analysis of PD-L1 expression both in cervical and lung cancer; b) the whole exome NGS of germinal DNA (gDNA) from the patient’s peripheral blood. Here, CD274 is linked to lung cancer.