Consistent with our data on the role of KIF23 in gastric cancer, KIF23 has been reported to affect the proliferation of glioma both in vivo and in vitro, which was regulated by TCF-4, suggesting a similar mechanism [28], whereas KIF23 could inhibit the development of lung cancer and promote apoptosis of lung cancer cells in vivo [13, 29]. The gene discussed is KIF23; the disease is central nervous system cancer.