Yuan [33] investigated the effect of ligustrazine (LIG is a purified and chemically identified component of the Chinese herb Ligusticum wallichii Franchat) on renal tubulointerstitial fibrosis using a rat model of unilateral ureteral obstruction, found that LIG significantly reduced the mRNA expression of TGF-β1, CTGF, monocyte chemoattractant protein-1, and osteopontin. The gene discussed is SPP1; the disease is Ureteral obstruction.