This particular study identified miR-1258 to be downregulated in CRC biopsies and representative cell lines, though its artificial upregulation led to an induction of cell cycle arrest at the G0/G1 phase in vitro and in vivo, together with inhibition of tumor cell proliferation through direct modulation of E2F Transcription Factor 8 (E2F8) [56]. Here, E2F8 is linked to colorectal carcinoma.