Moreover, concomitant leptin treatment and miR-4443 transfection led to a severe downregulated expression level for Nuclear Receptor Coactivator 1 (NCOA1) and Tumor Necrosis Factor receptor-associated factor 4 (TRAF4), as both are confirmed target genes for miR-4443 and also previously established in orchestrating tumor metastasis properties [58]. Here, TRAF4 is linked to neoplasm.