Blood samples were collected from four CRC patient/control groups (34 CRC obese, 36 CRC lean, 22 obese control, and 24 lean control), with consequent serum analysis for circulating miRNA profiling and including peripheral blood mononuclear cell (PBMC) PPAR-γ expression level and degree of its promoter methylation [60]. This evidence concerns the gene PPARG and colorectal carcinoma.