Further analysis for this novel circulating miRNA obesity biomarker, involving miRNA mimics/antagonists transfected in liver hepatocellular carcinoma cell line (HepG2 cells), demonstrated that miR-758-3p acts directly on the cholesterol efflux regulatory protein/ATP-binding cassette transporter type A1 (CERP/ABCA1) protein expression levels in a concomitant manner [46]. This evidence concerns the gene ABCA1 and obesity due to melanocortin 4 receptor deficiency.