Compared to the blank group, the weight of tumor in the si-LINC01314 group was noted to be increased (p < 0.05), while the OE-LINC01314, si-KLK4, and OE-LINC01314 + si-KLK4 groups displayed reductions in the weight of tumors in nude mice (p < 0.05). The gene discussed is KLK4; the disease is neoplasm.