FOXO3 and cancer: And it exerts an important role in different cancers: Kumazoe et al. proved the FOXO3/PGC-1β signaling axis was essential for sustain the pancreatic ductal adenocarcinoma cancer stem cell properties [37]; Bellafante et al. reported the overexpression of PGC-1β has the ability to provide balance between enhanced mitochondrial activity and promoted intestinal carcinogenesis [38].