Importantly, four lncRNAs (MYCNOS, DLX6-AS1, LINC00221, and CRNDE) and two mRNAs (CCNB1 and SHCBP1) were remarkably related to the prognosis of patients with HCC in both the TCGA and GEO databases. This evidence concerns the gene DLX6 and hepatocellular carcinoma.