HCC samples in the CCNB1 high-expression group were most significantly enriched for “sister chromatid segregation” (Fig. 4e) (Additional file 11: Table S11); HCC samples in the SHCBP1 high-expression group were most significantly enriched for “regulation of nuclear division” (Fig. 4f) (Additional file 12: Table S12). Here, SHCBP1 is linked to hepatocellular carcinoma.