CDK2 and cancer: We observed upregulation of different cyclins (CCNA2, CCNB1, CCNB2), cyclin dependent kinases (CDK2), cell cycle associated transcription factors (E2F6, E2F7, E2F8) and phosphatases (CDC20, CDC25A, CDC25C) in HCC, which agrees with the existing literature reporting the overexpression of cell cycle related genes in different cancer types including HCC [54–56].