Our data revealed an increase in expression of cpb transcripts from baseline to post-macrophage infection at 24 and 48 h, and such a response, assuming correlation of RNA and protein levels, may correlate with disease severity through dampening of a Th1-directed cytokine profile and immunologic response to infection, which has been demonstrated in previously published in vivo models [6, 37, 39]. Here, CPB1 is linked to infection.