SMAD4 and malignant colon neoplasm: miR‐19b‐3p is another member of the miR‐17‐92 cluster.44 It has been frequently recognized as onco‐miR and was found to be amplified in multiple tumor types.45 In Jiang's study, miR‐19b‐3p was found to be high expressed in colon cancer cells and could promote proliferation and chemoresistance by targeting SMAD4.