ASXL1 is a co-factor of the Polycomb repressive complex 2 (PRC2), and loss of function (Abdel-Wahab et al., 2012) and expression of dominantly acting truncated ASXL1 variants (Balasubramani et al., 2015, Guo et al., 2018) have been associated with transcriptional misregulations in hematological disorders. This evidence concerns the gene ASXL1 and hematologic disorder.