In this study, Drukker and colleagues developed human pluripotent stem cell models for the rare congenital disorder Bohring-Opitz syndrome, which is caused by mutations in the Polycomb factor ASXL1. In these lines, they found impaired neural crest emigration in vitro and in vivo and link this phenotype to impaired activation of ZIC1. The gene discussed is ASXL1; the disease is Bohring-Opitz syndrome.