GATA4 and pancreatic agenesis: To date, pathogenic variants in six genes (PTF1A [MIM: 615935], PDX1 [MIM: 260370], GATA6 [MIM: 600001], GATA4 [MIM: 600576], HNF1B [MIM: 137920], and RFX6 [MIM: 615710]) have been reported to severely affect pancreatic development and result in pancreatic agenesis.1