Since inefficient clearance of Aβ may play a determinant role in AD pathogenesis [67], we analyzed the effect of gal3 in two major mechanisms involved in Aβ clearance: Aβ phagocytosis and IDE-1 levels, a key metalloprotease involved in Aβ degradation by microglia [48]. This evidence concerns the gene LGALS3 and Alzheimer disease.