Interestingly, genes associated with the recently characterized neurodegenerative disease-associated phenotype (DAM microglia [27, 30]), such as Clec7a, Csf1, Cd74, Cxcl10 and Cybb (Fig. 3a, b, d), were downregulated in 5xFAD/Gal3KO mice compared to 5xFAD mice. Here, CYBB is linked to neurodegenerative disease.