Studies have also shown close spatial relationships between tau-PET uptake and grey matter volume in typical and atypical clinical variants of AD (Dronse et al., 2017; Iaccarino et al., 2018; Ossenkoppele et al., 2016; Sintini et al., 2018; Whitwell et al., 2018; Xia et al., 2017) and demonstrated that tau uptake is also related to antecedent rates of volume loss (Das et al., 2018; Gordon et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.