The greatest age effects were observed in frontal ROIs, with, for example, every decade resulting in up to 0.08 SUVR (right frontal mid) slower annual rate of tau accumulation in atypical AD, i.e. a 75 year old accumulated tau at an annual rate that is up to 0.08 SUVR slower than the annual rate of a 65 year old (Fig. 1, right). This evidence concerns the gene MAPT and Alzheimer disease.