There were significant differences in hypertension, ISS stage, hemoglobin, BUN, creatinine, GFR, LDH, and β2‐microglobulin between the two groups, while no differences in age, sex, diabetes, light chain isotype, IgA isotype, leukocyte, thrombocyte, globulin, albumin, alkaline phosphatase, calcium, or myeloma cell. This evidence concerns the gene HLA-G and hypertensive disorder.