To gain mechanistic insight into the anti-proliferative action of fenofibrate in MS1 VEGF angiosarcoma cells and to test the relevance of PPARα and NFκB, experiments were performed using: (a) WY14643 - potent and specific PPARα agonist (b) bezafibrate and fenofibric acid (c) GW6471 - PPARα antagonist and (d) PDTC - NFκB inhibitor (Fig. 5a). This evidence concerns the gene PPARA and angiosarcoma.