To summarize, using lentiviral vector expressing Dox-inducible c-Myb shRNA in in vitro experiments resulted in efficient suppression of c-Myb and inhibition of eRMS tumorigenesis, however, in experimental tumors, Dox induction of Myb shRNA was less effective, and we detected various levels of c-Myb ranging from low levels to the levels similar to control tumor (detected by IHC and western blotting) with no inhibitory effect on tumor growth. Here, MYB is linked to neoplasm.