MACROD2 and autism: The CpG site that yielded the largest statistically significant inverse association, cg07850633, was within the body of the MACRO domain-containing protein 2 (MACROD2) gene; which has been associated with autism spectrum disorder (ASD)69, though other studies have yielded potentially contradictory evidence70, autism-like traits71and has been implicated in other neurological disorders72,73, and temporal lobe volume74.