According to the UbiBrowser database (http://ubibrowser.ncpsb.org/), ARHGAP26 is predicted to be ubiquitinated by multiple E3 ubiquitin ligases, such as SMURF1, CBL, NEDD4, MDM2, and WWP1, which have been found to be dysregulated in ovarian cancer and associated with ovarian cancer cell proliferation and metastasis15,19–22. The gene discussed is SMURF1; the disease is ovarian cancer.