IRF7 and experimental autoimmune encephalomyelitis: Furthermore, Irf7, a critical transcription factor for the induction andpositive feedback regulation of type I IFN signaling (Seth et al., 2006), has been foundupregulated in experimental autoimmune encephalomyelitis (EAE; Salem et al., 2011) andis known to play a critical role with Tgfβ in microglia inflammatory response(Cohen et al.,2014).