PYCARD and neurodegenerative disease: Similar to several other neurodegenerative diseases (Heneka et al., 2018), evidence ofinflammasome activation through Nlpr3 expression was detected inthe Tpp1–/– mouse brain, including transcriptional upregulation of key components ofthat multimolecular signaling complex (i.e., Aim2,Pycard, Naip members, andPanx1).