DIRAS3 and neoplasm: The lncRNA growth arrest-specific 5 (GAS5) has been reported to suppress tumor proliferation, migration, and the EMT in osteosarcoma directly sponging miR-221 to inhibit its function and enhance aplasia Ras homologue member I (ARHI) expression, which is a tumor suppressor gene in osteosarcoma, down regulated in several cancers [104].