Furthermore, SFN decreased HDAC activity, which led to increased p21 and Bax protein expression levels and induced growth arrest in the G2/M phase and apoptosis in murine melanoma (B16) (concentrations ranging between 3–12 μM), human glioma (U251) (12 μM) [179] and human lung cancer (A549) (15 μM) cells [187]. Here, BAX is linked to melanoma.