Exposure of primary normal human bronchial epithelial cells (NHBE) and lung adenocarcinoma cells (A549) to both broccoli sprout extracts as well as individual ITCs (e.g., SFN, BITC and PEITC) have led to upregulation of GSTP1 (Glutathione S-transferase P) and NQO1 (NAD(P)H dehydrogenase [quinone] 1) phase II enzymes [89]. This evidence concerns the gene GSTP1 and lung adenocarcinoma.