HPGDS and cancer: Over the last decades, ITCs have raised scientific interest as agents capable of preventing cancer development [63,232,233,234,235,236,237], though such protective effects might depend on the individual’s genetic variation in (glutathione S –transferase) GST genes, given their important role in the metabolism and excretion of ITCs as well as in the inactivation of xenobiotics [238,239,240].