BITC, at 2 μM and 5 μM, was also shown to be effective in inhibiting new capillary formation and invasion of human glioma cells as well as causing G2/M arrest by regulating the expression of molecules important for cell cycle progression (cyclin B1 and p21) and the neo-angiogenetic process (MMPs-2 and -9 and vascular endothelial cadherin (VE-cadherin). Here, CDH5 is linked to central nervous system cancer.