Exposure of prostate cancer cells to PEITC (5 μM and 7.5 μM) and SFN (20 μM and 30 μM) significantly inhibited phosphorylation of IKK/IκB kinases and p65 as well as NFκB subunit nuclear translocation, thus suppressing the expression of NFκB-related genes (e.g., VEGF, cylcin D1 and B-cell lymphoma-extra large (Bcl-XL) leading to disturbing angiogenesis and invasion [269]. The gene discussed is NFKB1; the disease is Familial prostate cancer.