A study by Yu et al., 1998 showed that exposure of human cervical cancer (HeLa) cells to PEITC (and other structurally related ITCs) (10 μM) induced apoptosis, while treatment of these cells with a caspase-3 inhibitor attenuated this phenomenon, thus suggesting that the apoptotic process is strongly linked with caspase-3 activity [109]. This evidence concerns the gene CASP3 and cervical carcinoma.