In murine (B16F-10) melanoma cells, activation of multiple caspases, pro- and anti-apoptotic proteins and pro-inflammatory cytokines (e.g., TNF-α, interleukin-1β, IL-6, IL-12p40 and NF-κB) were all shown to be involved in SFN-induced apoptosis (1–5 μM) [304]. Here, TNF is linked to melanoma.