Inhibition of growth (at the G0/G1 phase) through modulation of p53, p21, p17, CDK2 and cyclin E activities was also observed in HSC-3 oral carcinoma cells after exposure to PEITC (0.5, 1, 2, 2.5 and 5 μM) [96]. This evidence concerns the gene TP53 and lip and oral cavity carcinoma.