DIO3 and neoplasm: Addition to the pro-tumour miRNAs up-regulated in TNBC by the absence of methylation, a set of miRNAs displaying anti-tumour characteristics were epigenetically inactivated by DNA methylation (DLK1-DIO3 cluster, miR126, miR195, miR497, miR148a, miR152 and miR-200 family) [126].