In 2017, it was demonstrated that CB2 and TRPV1 receptors can interfere with tumor growth and invasion in several OS cell lines (MG-63, U-2 OS, MNNG/HOS, Saos-2, KHOS/NP, and Hs888Lu) when stimulated, respectively, with JWH-133 and RTX, two selective agonists [102,103]. The gene discussed is CNR2; the disease is neoplasm.