The microtubule stabilizing factor APC, despite regulating differentiation and cell cycle arrest [564,565], might also be part of the migratory machinery of glioma cells, as it was recently shown that vimentin, GFAP, and nestin organization, along microtubules in the glioblastoma cell line U138-MG, is critically dependent on APC [456]. This evidence concerns the gene APC and central nervous system cancer.