LMNA and lipodystrophy: These laminopathies are caused mainly by mutations in the genes encoding the nuclear lamins, particularly in LMNA, the gene encoding lamins A and C. Over 600 different LMNA mutations cause a wide range of diseases, including Hutchinson-Gilford Progeria Syndrome, Emery-Dreifuss Muscular Dystrophy, dilated cardiomyopathy, and lipodystrophy [6,7].