Notably, CTC transcriptomic analyses performed in our laboratory indicated highest expression of Nodal [3], an embryonic morphogen of the transforming growth factor-beta (TGF-β) superfamily, shown to be expressed in aggressive cancers, e.g., triple negative breast and melanoma cancers, supporting tumor progression and resistance to conventional chemotherapies [19,20,21]. The gene discussed is NODAL; the disease is neoplasm.