We have previously shown that certain lung cancer lines, such as TC1 lung adenocarcinomas [36], grow as syngeneic tumors in WT mice and that anti-tumor immunity exerted by host CD8 T cells in these mice is restrained by Foxp3+ Treg cells; e.g., conditional deletion of p300 or CBP in Foxp3+ Treg cells, or use of a pharmacologic inhibitor directed again p300 and CBP, restores anti-tumor immunity and limits tumor growth [10]. The gene discussed is EP300; the disease is lung adenocarcinoma.