Thus, mice with conditional deletion of both CBP/Kat3a and p300/Kat3b in their Tregs develop severe autoimmunity and die in early life [13], similarly to Scurfy mice that have a loss of function deletion in Foxp3 [14], while deletion of either CBP or p300 results in only a modest decrease in Treg suppressive function. The gene discussed is EP300; the disease is Autoimmunity.