Indeed, n-3 PUFA may also alleviate IR, lipid accumulation, pro-inflammatory actions, and ROS production, and promote the FAO in NAFLD, in part by modulating the production of bioactive adipokines (leptin and adiponectin) that control the crosstalk between adipose tissue and key metabolic organs such as the liver and muscle [115]. This evidence concerns the gene LEP and metabolic dysfunction-associated steatotic liver disease.