Indeed, n-3 PUFA may also alleviate IR, lipid accumulation, pro-inflammatory actions, and ROS production, and promote the FAO in NAFLD, in part by modulating the production of bioactive adipokines (leptin and adiponectin) that control the crosstalk between adipose tissue and key metabolic organs such as the liver and muscle [115]. Here, ADIPOQ is linked to metabolic dysfunction-associated steatotic liver disease.