Moreover, the data revealed that SMURF2 tumor suppressor activities were associated with and at least in part relied on its ability to regulate RNF20, another E3 ligase and chromatin modifier responsible for histone H2B mono-ubiquitination and, thereby, for the regulation of chromatin compaction, gene expression and DNA damage response [6,10,11,12,13]. Here, SMURF2 is linked to neoplasm.