Osaki et al. reported that miR-143-3p expression decreased in a metastatic osteosarcoma cell line (143B) and primary osteosarcoma tissues with lung metastasis, resulting in an increase in the expression of MMP-13, which is a target gene of miR-143-3p, and hence, the invasion capability of the cell line increased [56]. The gene discussed is MMP13; the disease is osteosarcoma.