MC4R and coronary artery disorder: For coronary artery disease, the OR (95% CI) per kg/m2 genetically lower BMI, was 0.94 (0.93–0.95) for the 97-variant polygenic score versus 0.82 (0.72–0.95) for the β-arrestin-biased MC4R GoF variants, Pheterogeneity = 0.07.