EPHX2 and inflammatory bowel disease: Compared to the normal colon, the IBD biopsies had increased EPHX2 IHC staining (Fig 4B, 4C, 4E, 4F, 4H and 4I) in the following structures: mucosal epithelium (grades 2–4 in 7 /8 patients), lamina propria leukocytes (grades 1–2 in 7 /8 patients), endothelium (grades 1–2 in 9 /10 patients), muscularis (grades 1–2 in 9 /10 patients), transmural inflammatory infiltrates (grades 1–4 in 9 /10 patients), germinal centers (grades 3–4) in 3 /4 patients), myenteric plexi (grades 2–3) in 6 /7 patients).