TRIM35 and inflammatory bowel disease: More recently, a GWAS study across several populations identified 38 novel IBD loci, including SNP rs17057051 on chromosome 8, in a locus containing the genes PTK2B (protein tyrosine kinase 2 beta), TRIM35 (tripartite motif containing 35) and EPHX2 [European odds ratio 0.94, European P-value 5.5 E -08] [16].