Study participants with HIV-HBV co-infection had statistically significant lower CD4+ T-cell count (213.0 cells/μl) compared to HIV mono-infected participants (386.0 cells/μl) (p<0.0001) and also compared to HIV-HCV co-infected patients (490.0 cells/μl) (p = 0.013).The mean HIV-1 viral load was 4.87log10 copies/mL and was significantly higher among participants with HIV-HBV co-infection compared to HIV-HCV co-infection (5.39 vs 4.50 log10 copies/mL respectively) (p = 0.011) as well as participants with HIV mono-infection (5.39 vs 4.82 log10 copies/mL respectively) (p<0.0001) (Table 2). The gene discussed is CD4; the disease is coinfection.