SERPINB5 and neoplasm: Following the hypothetical tumor progression sequence of IM → LGD → HGD → ECA/GEJ Aca in situ → WD-ECA/GEJ Aca → MD-ECA/GEJ Aca → PD-ECA/GEJ Aca, the level of maspin expression, as judged by the intensity of the maspin IHC signal, progressively decreased (Fig 2D, 2F, 2H, 2J and 2L).