The HER2+ tumor environment is an especially attractive target for radiogenomic subtyping, as it contains a wide range of prognostic factors that vary between its molecular subtypes.34 Our findings provide new insight into HER2+ tumor biological characteristics and its radiographic phenotype, as the superior discriminability of peritumoral radiomic features appears to suggest discriminable differences of the tumor environment between the intrinsic molecular subtypes of HER2+ breast cancer. This evidence concerns the gene ERBB2 and neoplasm.