Figure 2B depicts representative heatmaps corresponding to top intratumoral (Laws ripple-ripple) and peritumoral (CoLlAGe inertia) features. As with HER2-E, expression of these features was elevated in patients who achieve pCR compared with other HER2+ breast cancers. Breast Imaging Reporting and Data System assessment of background parenchymal enhancement and fibroglandular tissue volume did not differ significantly between response groups (eTable 7 in the Supplement). This evidence concerns the gene ERBB2 and breast cancer.