Our approach represents several possible contributions to the area of breast radiogenomics: (1) radiogenomic subtyping of HER2+ breast cancer using both intratumoral and peritumoral textural patterns, (2) applying radiogenomic subtyping to the assessment of response to a specific targeted therapy, and (3) substantiating radiogenomic signatures through morphologic association with corresponding biopsy samples. This evidence concerns the gene ERBB2 and breast cancer.