EGFR and ovarian carcinoma: Research into the mechanisms of EGFR overexpression has focused on mutations and amplifications in the coding region of the gene containing the receptor tyrosine kinase domain.63 However, few studies on SNP variants in this region have been linked to EOC or other ovarian cancer histologic subtypes.61, 63EGFR SNP rs114972508 is located in intron 1 of the EGFR gene.