In this study, SNPs from 11 gene regions: VDR, EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC, were genotyped, imputed then assessed for risk of EOC and high grade serous ovarian cancer (HGSOC) in cases and controls of AA from the African American Cancer Epidemiology Study (AACES)40 and the Ovarian Cancer Association Consortium (OCAC).41 The gene discussed is EGFR; the disease is ovarian cancer.