The EGFR gene product has been a chemotherapeutic target for EOC since overexpression has been linked to poor prognosis in ovarian cancer patients.60, 61, 62 The signaling pathway for EGFR is mediated by ligands including the epidermal growth factor in the regulation of cell proliferation, differentiation and apoptosis in normal cells. The gene discussed is EGF; the disease is ovarian carcinoma.