In literature, many clinical, biochemical, and radiological characteristics have been investigated as potentially predictive factors for long-term remission in prolactinomas, like treatment duration, complete tumor regression before withdrawal, and nadir PRL reached during dopamine agonist treatment [22, 25, 26, 33–35], and some were included by most recent guidelines as criteria for drug withdrawal [2, 3]. Here, PRL is linked to neoplasm.