GSTP1 and Hepatic fibrosis: In addition, mice fed with probiotic MIYAIRI 588 decreased the deposition of hepatic fibrosis as well as the development of hepatocarcinogenesis and GST-P-positive foci by increasing the activation of adenosine 5-monophosphate-activated protein kinase (AMPK), protein kinase B (PKB), and the expression of lipogenesis-related proteins [17].